Sex, dietary salt and AT2R impact sodium transporters along the nephron
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چکیده
منابع مشابه
Distribution of transporters along the mouse distal nephron: something old, something borrowed, something new.
THIS ISSUE OF the American Journal of Physiology: Renal Physiology contains two important papers describing the immunolocalization of transporters in the distal tubules of the mouse (3, 6). There are many reasons for the special interest in the organization of this region of the mouse nephron. The distal convoluted tubule (DCT) plays a critical role in regulating renal Na, Ca, and Mg excretion ...
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Renal functions are regulated by steroid sex hormones, but the exhaustive identification of their receptors along the nephron is still lacking. Here, we have localized all known nuclear or membrane-bound sex hormone receptors and some of their activators along the nephron of male and female mice. Almost all receptors are present in male and female kidney, some of them having very restricted loc...
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The final adjustment of renal sodium and calcium excretion is achieved by the distal nephron, in which transepithelial ion transport is under control of various hormones, tubular fluid composition, and flow rate. Acquired or inherited diseases leading to deranged renal sodium and calcium balance have been linked to dysfunction of the distal nephron. Diuretic drugs elicit their effects on sodium...
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Excessive or high salt or sodium intake is known to cause hypertension and other diseases. Within the United Kingdom voluntary targets for salt reduction have been set and laid out in the Secretary of State responsibility deal. This review considers the options available to food manufacturers to enable them to reduce salt and the potential food safety risks associated with those options. Gaps i...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.864.13